Koagulon™ vitamin K1 injection

Description

Presentation:

20 mL multi-dose vial.

Active Constituents:

Each mL contains: Phytomenadione 10 mg.

Properties:

KOAGULONTM vitamin K1 injection contains phytomenadione (Vitamin K1), which is essential for the hepatic biosynthesis of coagulation proteins, Factors II, VII, IX and X. A transient metabolite of vitamin K is thought responsible for activation of clotting factors, following which the metabolite is converted to vitamin K epoxide. The cycle is completed by the enzyme vitamin K reductase.

Anticoagulant rodenticides compete with vitamin K epoxide for the receptor site on vitamin K reductase, preventing vitamin K regeneration. Depletion of available vitamin K soon occurs and insufficient metabolite is available for activation of clotting factors. Normal coagulation processes are then inhibited by the lack of clotting factors.

Dicoumarol is the substance responsible for haemorrhage in sweet clover poisoning. Its mode of action is identical to that of the anticoagulant rodenticides, indanediones and warfarin.

Phytomenadione is more effective than menadione (vitamin K3) in the treatment of anticoagulant rodenticide toxicosis.

Dosage and Administration:

This product may be given only by, or under the supervision of, a registered veterinarian.

Dogs and Cats: 0.25 – 2.5 mg/kg (0.25 – 2.5 mL per 10 kg) bodyweight by intramuscular or subcutaneous injection or by slow intravenous injection in 5% Dextrose solution at a rate not greater than 1 mg per minute.

Horses and Cattle: 0.5 – 2.5 mg/kg (5 – 25 mL per 100 kg) bodyweight by subcutaneous or intramuscular injection twice daily.

High doses and long-term therapy may be required for second generation coumarin-type rodenticides or indanediones.

Withholding Period:

Nil

Regulatory Status:

Restricted Veterinary Medicine, available only under veterinary authorisation. Registered pursuant to the ACVM Act 1997, No. A010507